What is lymphomatoid granulomatosis of the lung? - granulomatosis
This disease is rare, and the underlying cause has been recently established, it is important to obtain current data about them. The name sounds as if it is benign, but in most cases, the lesion is a B-cell lymphoma (cancer) cell. The patient with this disease usually presents with multiple necrotic foci in the lungs. The biopsy showed a variable number of neoplastic tumor cells (B-) cells surrounded by reactive inflammation.
Lymphomatoid granulomatosis is a disease that has made forty years ago by the microscopic image (before they knew it was malignant). System is the most current World Health Organization classified into three categories (I to III). The grade is determined by the number of atypical cells and the levels of tumor necrosis. The lesions I show little atypia and no necrosis. The lesions of higher grade (II and III) showed more necrosis and atypia. The tumor is determined by the Epstein-Barr virus causes B-lymphocyte driven. Tumors of higher grade (grade II and III) are typically treated lymphoma with chemotherapy, while inferior tumors (grades I and II) are some of them are often treated with interferon.
The diagnosis is a biopsy tissue. The diagnosis is so rare that I want an expert to examine the tissue. It is important to a coloring of B-cells (eg CD20) and a point on the Epstein-Barr have made.
Granulomatosis What Is Lymphomatoid Granulomatosis Of The Lung?
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With a lung cancer or lung tumors in the granulosa cells.
Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr (EBV) associated lymphoproliferative disorders with a tendency to destroy the blood vessels.
The disease was first recognized as classified granulomatous vasculitis and lung, but now, as lymphoproliferative syndrome with distinct angiotropism.
In most cases, represent "EBV-associated lymphoproliferative syndrome TB rich", although some believe that many of these cases as a synonym for angiocentric B-cell non-Hodgkin's lymphoma.
Clinical Presentation: The average age at diagnosis is around 50 years, especially men. Present vague respiratory symptoms (cough, dyspnea, hemoptysis and chest pain) patients and found that lung nodules and masses in May cavitation.
Overall image shows multiple bilateral nodes, but one-sided disease is also described.
Lymphomatoid granulomatosis is both aggressive and associated with high mortality without treatment.
A recent study showed a good response to treatment with interferon alfa-2b and notalso has a report on the successful treatment with bone marrow transplantation.
More information: http://www.histopathology-india.net/lymphomatoid_granulomatosis.htm
Exactly what it says ... Granular cancer of the lymphatic system of the lung.
(Cancer of the lymphatic system in the lungs ... sown in small pieces, such as gravel.)
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